Start with the part that gets in your way. Reading small text, following a pointer, hearing audio, and using a mouse are different needs. Choose one thing to improve and review the relevant accessibility options on your own device.

Name the difficulty in your own words.
“I lose the pointer” is a useful description. So is “I need the words bigger.” You do not need a diagnosis or technical vocabulary to ask for a different experience.
Try one adjustment at a time.
Write down the original setting before changing it. Test the change in the app or website you use most. Keep it if it helps, or return to the previous setting if it does not.
Keep choice in the interface.
A keyboard, mouse, touch screen, voice input, or assistive device may be useful in different situations. An easier interface should not require everyone to use the same method.
Check the instructions for your device.
Use the current accessibility guide from your operating-system provider. Names and locations of settings can vary. Do not install an unknown “accessibility fixer” just because an advertisement promises a one-click solution.
Official starting points: Microsoft’s Make text and apps bigger for Windows, and Apple’s Get started with accessibility features on Mac.
AskKip’s approach.
Our website is being built with readable text, labeled controls, and keyboard use in mind. The desktop app is not yet available. You can report a website barrier without telling us private medical information.